姓名:张建华 博士,硕士生导师
职称职务:教授,金沙2004路线js5医学检验系主任
社会兼职:浙江省微生物学会第十二届理事会理事;第六届浙江省免疫学会基础免疫专业委员会委员
研究方向:病毒抗原表位鉴定及应用研究
主讲课程:《医学免疫学》
发表代表性论文:
[1]Zhao J, Wang Q, Zhang J. Changes in Microbial Profiles and Antibiotic Resistance Patterns in Patients with Biliary Tract Infection over a Six-Year Period. Surg Infect (Larchmt). 2019;20:480-485.
[2]Zhang J, Huang H, Xu L, et al. Screening and Identification of Linear B Cell Epitopes Within the Nonstructural Proteins of Enterovirus 71. Viral Immunol. 2019;32:84-88.
[3]张建华, 应安娜, 俞梦琪, 俞冰楠. 利用RNA-seq数据分析肝细胞癌差异表达基因及蛋白相互作用. 基因组学与应用生物学. 2019;38:461-467.
[4]张建华, 徐莲, 黄慧琪, 等. 肠道病毒71型感染致中枢神经系统损害的免疫发病机制. 中国免疫学杂志. 2019;35:1266-1270.
[5]Chen X, Qin B, Shi M, et al. Immunoreactivity Analysis of the Nonstructural Proteins of Human Enterovirus 71. Viral Immunol. 2017;30:106-110.
[6]Xu M, Behloul N, Wen J, et al. Role of asparagine at position 562 in dimerization and immunogenicity of the hepatitis E virus capsid protein. Infect Genet Evol. 2016;37:99-107.
[7]Qin B, Zhang J, Xie W, et al. Development of a Specific Latex Agglutination Test to Detect Antibodies of Enterovirus 71. Arch Med Res. 2015;46:580-587.
[8]Zhang J, Jiang B, Xu M, et al. Identification of specific antigenic epitope at N-terminal segment of enterovirus 71 (EV-71) VP1 protein and characterization of its use in recombinant form for early diagnosis of EV-71 infection. Virus Res. 2014;189:248-253.
[9]Zhang J, Dong M, Jiang B, et al. Antigenic characteristics of the complete and truncated capsid protein VP1 of enterovirus 71. Virus Res. 2012;167:337-342.
[10]Jiang B, Zhang J, You X, et al. Diagnosis of hand, foot, and mouth disease caused by EV71 and other enteroviruses by a one-step, single tube, duplex RT-PCR. J Med Virol. 2012;84:1803-1808.
[11]Zhang J, Wang Q, Zhao D, Cao X. Induction of potent anti-tumor immunity by direct injection of Ad-LIGHT at the site of tumor inoculation. Cytotherapy. 2007;9:386-396.
[12]张建华, 赵德矿, 王青青, 等. IL-12基因联合CD40L基因治疗小鼠黑色素瘤的实验研究. 中国免疫学杂志. 2007;23:426-429.
主持或参与的课题:
[1]肠道病毒71型非结构蛋白B细胞表位的筛选与鉴定研究(LY16H190005),浙江省自然科学基金年度项目(主持),2016.01-2019.12
[2]CBL与LBL相结合在临床医学专业医学免疫学教学中的应用,浙江省高等教育课堂教学改革项目(主持),2016.11-2018.11
[3]肠道病毒71型结构蛋白VP1特异性抗原的筛选及其应用研究(2011A33003),绍兴市科技局年度项目(主持),2011.09-2014.06
[4]FER激酶在肝细胞癌转移中的双向调控及机制研究(81101612),国家自然科学基金委员会年度项目(参与),2011.09-2014.12
[5]伤寒和副伤寒通用型糖肽结合疫苗构建及免疫保护性研究(Y2090395),浙江省自然科学基金年度项目(参与),2009.01-2012.12